Search results for " Inflammatory Cytokines"

showing 3 items of 3 documents

Biomarkers for vascular ageing in aorta tissues and blood samples.

2019

Abstract Objectives Functional and quantitative alterations and senescence of circulating and expanded endothelial progenitor cells (EPC), as well as systemic and tissue modifications of angiogenetic and inflammatory molecules, were evaluated for predicting age-related vessel wall remodeling, correlating them to intima media thickness (IMT) in the common carotid artery (CCA), a biomarker of early cardiovascular disease and aortic root dilation. Populations and methods A homogenous Caucasian population was included in the study, constituted by 160 healthy subjects (80 old subjects, mean age 72 ± 6.4, range 66–83 years; and 80 younger blood donors, mean age 26.2 ± 3.4, range 21–33 years), and…

0301 basic medicineMaleVascular Endothelial Growth Factor AAgingPhysiologySystemic inflammationBiochemistryCarotid Intima-Media Thickness0302 clinical medicineEndocrinologySA-β-Gal activityp21 and p16 genesMedicineTP53Receptor Notch1AortaEndothelial Progenitor CellsAged 80 and overeducation.field_of_studyChemotaxisInflammatory cytokinesmedicine.anatomical_structurecardiovascular systemBiomarker (medicine)Femalemedicine.symptomTP53 p21 and p16 genesSenescenceAdultEndotheliumInflammatory cytokineNotch and TLR4Carotid Artery CommonPopulationProinflammatory cytokine03 medical and health sciencesYoung AdultTP53 p21 and p16 genemedicine.arteryGeneticsHumansEPC cell populationeducationMolecular BiologyEPC cell populationsAgedAortabusiness.industryEndothelium age-related impairmentCell BiologyChemokine CXCL12Toll-Like Receptor 4EPC cell populations; Endothelium age-related impairment; Inflammatory cytokines; Notch and TLR4; SA-β-Gal activity; TP53 p21 and p16 genesSettore MED/23030104 developmental biologyIntima-media thicknessbusiness030217 neurology & neurosurgeryBiomarkersExperimental gerontology
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A NOVEL APPROACH IN COLORECTAL CANCER AND DIABETES MANAGEMENT: ROLE OF METFORMIN AND RAPAMYCIN

Abstract The link between colorectal cancer (CRC), diabetes mellitus (DM) and inflammation is well established, and polytherapy, including rapamycin, has been commonly adopted. However, due to the relatively weak response of CRC to rapamycin, combination with other molecules including metformin has become a potentially promising approach. This study is a novel approach that aimed at assessing the effect of a combination therapy of metformin and rapamycin on the control or prevention of colorectal cancer in diabetic animals, in presence or absence of probiotics. Fifty NOD/SCIDs male mice developed xenograft by inoculating HCT116 cells into the flank; they were equally divided into diabetics …

CRC DM Probiotics Inflammatory Cytokines AMPK mTOR ROS.Settore MED/09 - Medicina Interna
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Effects of n-3 Polyunsaturated Fatty Acids (ω-3) Supplementation on Some Cardiovascular Risk Factors with a Ketogenic Mediterranean Diet

2015

Background: the ketogenic diet (KD) has become a widely used nutritional approach for weight loss. Some of the KD’s positive effects on metabolism and cardiovascular risk factors are similar to those seen after n-3 polyunsaturated fatty acids (ω-3) supplementation. We hypothesized that a ketogenic Mediterranean diet with phytoextracts combined with ω-3 supplementation may have increased positive effects on cardiovascular risk factors and inflammation. Methods: We analyzed 34 male overweight subjects

cardiovascular risk factorsBlood GlucoseMaleMediterranean dietinflammatory cytokinesmedicine.medical_treatmentN-3 polyunsaturated fatty acidPharmaceutical ScienceOverweightDiet Mediterraneanchemistry.chemical_compoundRisk FactorsWeight lossDrug DiscoveryInsulinlcsh:QH301-705.5Pharmacology Toxicology and Pharmaceutics (miscellaneous)Adipositychemistry.chemical_classificationCardiovascular risk factors; Inflammatory cytokines; Ketogenic diet; N-3 polyunsaturated fatty acids; Omega-3; Weight loss; Drug Discovery3003 Pharmaceutical ScienceMiddle Agedn-3 polyunsaturated fatty acidsketogenic dietCardiovascular DiseasesCytokinesomega-3medicine.symptomDiet KetogenicPolyunsaturated fatty acidAdultmedicine.medical_specialtyInflammatory cytokineBiologyCardiovascular risk factorWeight loArticleInternal medicineFatty Acids Omega-3Weight LossmedicineHumansTriglyceridesAgedAdiponectinPlant ExtractsCholesterolDrug Discovery3003 Pharmaceutical Science<i>n</i>-3 polyunsaturated fatty acidsCholesterol LDLOverweightEndocrinologylcsh:Biology (General)chemistryDietary SupplementsUric acidKetogenic dietMarine Drugs
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